Intravaginal ring devices
AssigneeDaré Bioscience, Inc.
InventorsDavid Friend, Jennifer Kiang, Nicolas Pacelli, Mark Walters
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Abstract
Disclosed herein are intravaginal ring (IVR) devices comprising barriers that may be metal, polymeric or combinations of metal and polymeric. The IVRs are useful for contraception, treating and/or preventing sexually transmitted diseases, and treating and/or preventing bacterial infections. The IVR's are resistant to distortion due to absorption of vaginal fluids. This allows the IVRs to perform better over time as compared to other intravaginal rings made with copolymeric silicone.
Claims164
An intravaginal ring device comprising a flat, circular or oval ring made with a non-segmented or segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, wherein the ring contains one or more active ingredients;
- and, wherein the ring encircles a curved or flat, non-resorbable metal barrier, polymeric barrier, combination metal and polymer barrier or a barrier made with perforated film, wherein the barrier is attached to the ring and the barrier is not fully occlusive to allow the passage of uterine secretions.
The intravaginal ring device according to 10, wherein the metal barrier is a mono- and/or multi-filament metal barrier.
The intravaginal ring device according to 18, wherein the metal barrier is a mono- and/or multi-filament metal barrier.
The intravaginal ring device of claim 23 wherein the perforated film comprises multiple layers that are offset.
The intravaginal ring of any one of 30-33, wherein the intravaginal ring further comprises active ingredients contained in discrete reservoirs and/or continuous sheathed in a polymer as part of the uncoated thermoplastic elastomer.
An intravaginal ring device comprising a saddle-shaped, oval ring made with a non-segmented or segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, wherein the ring contains one or more active ingredients;
- and, wherein the ring encircles a curved, non-resorbable metal barrier, polymeric barrier, combination metal and polymer barrier or a barrier made with perforated film, wherein the barrier is attached to the ring and the barrier is not fully occlusive to allow the passage of uterine secretions.
The intravaginal ring of any one of 65-68, wherein the intravaginal ring further comprises active ingredients contained in discrete reservoirs and/or continuous sheathed in a polymer as part of the thermoplastic elastomer.
The intravaginal ring device according to any one of 34-69 wherein the intravaginal ring has less distortion after storage or after insertion into a subject for at least 14 days when compared to an intravaginal ring device made with a copolymeric silicone matrix in which both rings contain equivalent amounts and composition of nonhormonal spermiostatic agents and/or ascorbic acid if present.
An intravaginal ring device comprising a flat, circular or oval ring made with a non-segmented or segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, wherein the ring encircles a curved or flat, non-resorbable metal barrier, polymeric barrier, combination metal and polymer barrier or a barrier made with perforated film, wherein the barrier is attached to the ring and said metal and polymer barriers and said perforated film contain active ingredients;
- wherein said barriers or perforated film is not fully occlusive to allow the passage of uterine secretions.
The intravaginal ring device according to 80, wherein the metal barrier is a mono- and/or multi-filament metal barrier.
The intravaginal ring device according to any one of claims 84-88, wherein the metal portion of the barrier comprises one or more of aluminum, copper, stainless steel, titanium, nickel, nickel-titanium, gold, silver, platinum or palladium.
The intravaginal ring device according to any one of 71-99 wherein the intravaginal ring has less distortion after storage or after insertion into a subject for at least 14 days when compared to an intravaginal ring device made with a copolymeric silicone matrix in which both rings contain equivalent amounts and composition of nonhormonal spermiostatic agents and/or ascorbic acid if present.
An intravaginal ring device comprising a saddle-shaped, oval ring made with a non-segmented or segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, wherein the ring encircles a curved or flat, non-resorbable metal barrier, polymeric barrier, combination metal and polymer barrier or a barrier made with perforated film, wherein the barrier is attached to the ring and said metal and polymer barriers and said perforated film optionally contain active ingredients;
- wherein said barriers or perforated film is not fully occlusive to allow the passage of uterine secretions.
The intravaginal ring device according to any one of 101-129 wherein the intravaginal ring has less distortion after storage or after insertion into a subject for at least 14 days when compared to an intravaginal ring device made with a copolymeric silicone matrix in which both rings contain equivalent amounts and composition of nonhormonal spermiostatic agents and/or ascorbic acid if present.
An intravaginal ring device comprising a flat, circular or oval ring made with a non-segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, wherein the ring contains one or more non-hormonal spermiostatic agents;
- and, wherein the ring encircles a curved, non-resorbable polymeric barrier which is attached to the ring;
- and wherein the ring covers the cervix when inserted into a subject.
An intravaginal ring device comprising a saddle-shaped, oval ring made with a non-segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, wherein the ring contains one or more non-hormonal spermiostatic agents;
- and, wherein the ring encircles a curved, non-resorbable polymeric barrier which is attached to the ring;
- and wherein the ring covers the cervix.
The intravaginal ring device according to claims any one of 143-151 wherein the intravaginal ring has less distortion after storage or after insertion into a subject for at least 14 days when compared to an intravaginal ring device made with a copolymeric silicone matrix in which both rings contain equivalent amounts and composition of nonhormonal spermiostatic agents and/or ascorbic acid if present.
An intravaginal ring device comprising a flat, circular or oval ring made with a segmented uncoated thermoplastic elastomer, excluding copolymeric silicone, with a removal tab, wherein the ring contains one or more non-hormonal spermiostatic agents;
- and, wherein the ring encircles a curved, non-resorbable polymeric barrier which is attached to the ring;
- and wherein the ring covers the cervix when inserted into a subject.
Dependencies are inferred from the claim text.