Devices and methods for multi-alignment of implantable medical devices

A transcatheter valve prosthesis comprising:

• a stent having a crimped configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve, wherein the stent comprises an inflow portion and at least one axial frame member;
• and
• at least one outflow marker positioned on the at least one axial frame member,
• wherein the outflow marker is visible relative to the stent in one or more images captured during delivery and deployment of the stent.

A delivery system for medical procedure, the system comprising:

• a shaft configured to deliver an implantable medical device for installation at a target site;
• one or more proximal alignment markers coupled to the shaft, wherein the one or more proximal alignment markers are positioned on the shaft at a first location that corresponds to a proximal end of the implantable medical device when in the radially expanded state;
• one or more distal alignment markers coupled to the shaft, wherein the one or more distal alignment markers are positioned on the shaft at a second location that corresponds to a distal end of the implantable medical device when in the radially expanded state;
• and
• one or more implant markers configured to be positioned on the implantable medical device, wherein:
• the one or more proximal alignment markers, the one or more distal alignment markers, and the one or more implant markers are visible in one or more images captured during the installation at the target site, and
• at least one of a shape of the one or more implant markers or a position of the one or more implant markers produces a visual reference in the one or more images for orienting the implantable medical device relative to a desired orientation at the target site.