Instrument delivery devices, systems, and methods to extend through a thrombus

A method, comprising:

• coupling a first delivery device to a catheter assembly, wherein the catheter assembly comprises a catheter dwelling within vasculature of a patient, wherein the first delivery device comprises:
• a first housing;
• and
• a first tubular instrument, comprising a distal end, a proximal end, and a lumen extending between the distal end of the first tubular instrument and the proximal end of the first tubular instrument, wherein the proximal end of the first tubular instrument is secured within the first housing, wherein the first tubular instrument is configured to advance distally from a proximal position to a distal position with respect to the first housing and the catheter assembly, wherein in response to the first tubular instrument being in the proximal position, the first tubular instrument is proximal to the catheter assembly, wherein in response to the first tubular instrument being in the distal position, a distal surface of the first tubular instrument is disposed distal to a distal tip of the catheter and at a first distance beyond the distal tip of the catheter;
• after transferring a first volume of blood via the first tubular instrument to a first blood collection container and moving the tubular instrument from the distal position toward the proximal position, decoupling the first delivery device from the catheter assembly;
• after decoupling the first delivery device from the catheter assembly, coupling a second delivery device to the catheter assembly, wherein the second delivery device comprises:
• a second housing;
• a second tubular instrument, comprising a distal end, a proximal end, and a lumen extending between the distal end of the second tubular instrument and the proximal end of the second tubular instrument, wherein the proximal end of the second tubular instrument is secured within the second housing, wherein the second tubular instrument is configured to advance distally from another proximal position to another distal position with respect to the second housing and the catheter, wherein in response to the second tubular instrument being in the proximal position, the second tubular instrument is proximal to the catheter assembly, wherein in response to the second tubular instrument being in the distal position, a distal surface of the second tubular instrument is disposed distal to the distal tip of the catheter and at a second distance from the distal tip of the catheter, wherein the second distance is greater than the first distance;
• and
• after transferring a second volume of blood via the second tubular instrument to a second blood collection container and moving the second tubular instrument from the distal position toward the proximal position, decoupling the second delivery device from the catheter.