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AssigneeHealth Research, Inc.
InventorsKunle ODUNSI, Takemasa TSUJI, Junko MATSUZAKI
Estimating the term…
Provided are modified cancer cells that are modified to co-express class II trans-activator (CIITA), and an immuno-stimulatory molecule. The immuno-stimulatory molecule is OX-40-ligand or 4-1BB-Ligand. Methods of making the cells are provided by introducing polynucleotides encoding the CIITA and the immune-stimulatory molecule into cancer cells. Methods of stimulating humoral and cell-mediated immune responses by administering the modified cancer cells, or polynucleotides encoding the CIITA and immune-stimulatory molecules are also provided. These approaches can be used to stimulate an immune response against any of a wide variety of cancer antigens.
Modified cancer cells that are modified to co-express class II trans-activator (CIITA), and an immuno-stimulatory molecule.
A method of making modified cancer cells for use in a cancer vaccine, the method comprising introducing into the cancer cells one or more polynucleotides that result in expression of class II trans-activator (CIITA), and an immuno-stimulatory molecule.
An isolated expression vector or combination of isolated expression vectors encoding class II trans-activator (CIITA) and an immuno-stimulatory molecule.
One or more modified cancer cells that is/are selected from the group consisting of breast cancer cell(s), prostate cancer cell(s), pancreatic cancer cell(s), lung cancer cell(s), liver cancer cell(s), ovarian cancer cell(s), cervical cancer cell(s), colon cancer cell(s), esophageal cancer cell(s), stomach cancer cell(s), bladder cancer cell(s), brain cancer cell(s), testicular cancer cell(s), head and neck cancer cell(s), melanoma cell(s), skin cancer cell(s), any sarcoma cell(s), leukemia cell(s), lymphoma cell(s), myeloma cell(s), and combinations thereof, wherein the one or more modified cancer cells express class II trans-activator (CIITA) and an immuno-stimulatory molecule from one or more recombinant polynucleotides.
Dependencies are inferred from the claim text.