Back to results
US 2021/0268082 A1Published application
METHOD OF INDUCING IMMUNE TOLERANCE BY ADMINISTERING ACTIVE PRINCIPLE-LOADING RBC's
AssigneeErytech Pharma
InventorsYann GODFRIN, Alice BANZ
Life of this patent
Estimating the term…
Abstract
The invention relates to a composition which induces, in a host, an immune tolerance to a peptidic or proteic active principle, said composition comprising red blood cells containing an active principle selected from the group consisting of a therapeutic peptide, polypeptide or protein, a peptidic or proteic autoantigen, peptide, polypeptide or protein inducing an allergic reaction and a transplantation peptidic or proteic antigen.
Claims12
1-38. (canceled)
A method for inducing immune tolerance in a human subject, the method comprising:
- administering, to a human subject in need thereof, an effective amount of an active principle to thereby induce immune tolerance to the active principle in the human subject,
- wherein the active principle is encapsulated in an erythrocyte comprising a modification that promotes targeting of the erythrocyte to the reticuloendothelial system of the liver and/or spleen,
- wherein the modification is formed by chemically treating the erythrocyte with an ionophore.
A method for inducing immune tolerance in a human subject, the method comprising:
- administering, to a human subject in need thereof, an effective amount of an active principle to thereby induce immune tolerance to the active principle in the human subject,
- wherein the active principle is encapsulated in an erythrocyte comprising a modification that promotes targeting of the erythrocyte to the reticuloendothelial system of the liver and/or spleen, wherein the modification is formed by chemically treating the erythrocyte with an ionophore, and
- wherein polyinosinic:polycytidylic acid (Poly(I:C)) is not administered to the subject.
Dependencies are inferred from the claim text.