Composition, comprising ß-glucan-peptide complex and antibiotic, for prevention, alleviation, or treatment of inflammatory disease

Abstract

The present invention relates to a composition for use in preventing, alleviating, or treating inflammatory disease, or an anti-inflammatory composition, which comprises: β-1,3-glucan; and the peptide composed of the amino acid sequence of SEQ ID NO: 4. The present invention also relates to an antibacterial composition against bacteria causative of sepsis, which comprises: β-1,3-glucan; the peptide composed of the amino acid sequence of SEQ ID NO: 4; and an antibiotic. The present invention also relates to a method for preventing or treating an inflammatory disease, the method comprising a step of administering β-1,3-glucan; and the peptide composed of the amino acid sequence of SEQ ID NO: 4 to a patient. Accordingly, when β-1,3-glucan and a peptide consisting of an amino acid sequence of SEQ ID NO: 4 are included, since the level of reactive oxygen species (ROS), sepsis-causing bacteria or an inflammatory cytokine of a sepsis mouse can be lowered, and the survival rate of the mouse can be significantly increased, they are effective for use in a composition or method for preventing, alleviating or treating an inflammatory disease such as sepsis. Particularly, the ROS generated by a phagocyte is specifically reduced and when used in combination with an antibiotic, ROS, sepsis-causing bacteria or the expression level of an inflammatory cytokine can be significantly decreased, thereby significantly increasing a survival rate, resulting in a more excellent effect.

Dependencies are inferred from the claim text.