Methods of treating cancer with tnf expressing myxoma virus
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsDouglas Grant MCFADDEN, John CHRISTIE, Joseph BLATTMAN, Mohammed Masmudur RAHMAN
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Abstract
Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.
Claims49
A myxoma virus (MYXV) engineered to express a tumor necrosis factor (TNF) protein, wherein the MYXV comprises a modification at or adjacent to one or more genes associated with rabbit cell tropism.
A composition comprising peripheral blood mononuclear cells (PBMCs), bone marrow (BM) cells, or a combination thereof treated ex vivo by a myxoma virus (MYXV) engineered to express a tumor necrosis factor (TNF) protein.
A method of inhibiting or treating a cancer in a subject in need thereof, comprising administering to the subject a myxoma virus (MYXV) engineered to express a tumor necrosis factor (TNF) protein.
Dependencies are inferred from the claim text.