Methods and compositions for treatment of solid cancers and microbial infection
AssigneeImmvira Co., Limited
InventorsGrace ZHOU, Xiaoqing CHEN
Life of this patent
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Abstract
Provided is a recombinant virus comprising a fragment of exogenous polynucleotides encoding suppressor of cytokine signaling 4 (SOCS4) or a functional fragment thereof, wherein the recombinant vims expresses SOCS4 or the functional fragment once replication in a cell. Also provided are use of a recombinant oncolytic virus for preparation of therapeutic drugs of cancer and side effects of virus infection.
Claims23
A recombinant virus comprising a fragment of exogenous polynucleotides encoding suppressor of cytokine signaling 4 (SOCS4) or a functional fragment thereof, wherein the recombinant virus expresses SOCS4 or the functional fragment once replication in a cell.
A method for treatment of cancer in a subject comprising administering to the subject a therapeutically effective amount of a recombinant oncolytic virus, wherein the recombinant oncolytic virus comprises a fragment of exogenous polynucleotides encoding suppressor of cytokine signaling 4 (SOCS4) or a functional fragment thereof and expresses SOCS4 or the functional fragment once replication in a cancer cell.
16-21. (canceled)
A method for reducing or eliminating side effects of treatment of microbial infection in a subject comprising administering to the subject a therapeutically effective amount of a recombinant virus comprising a fragment of exogenous polynucleotides encoding suppressor of cytokine signaling 4 (SOCS4) or a functional fragment thereof, wherein the recombinant virus expresses SOCS4 or the functional fragment once replication in a cell.
Dependencies are inferred from the claim text.