Pharmaceutical composition for topical wound treatment
AssigneesConsejo Nacional De Investigaciones Cientificas Y Tecnicas, Universidad Nacional De Tucuman, Untech Inc.
InventorsAlberto RAMOS VERNIERI, Maria DE LOS ANGELES LAZARTE, Romina Mabel CHAVEZ JARA, Nicolas Abel CERUSICO
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Abstract
A pharmaceutical composition for topical wound treatment comprising one or more nitrogenous heterocyclic compound of 5 or 6 atoms with imide group; one or more deoxyribonuclease enzyme with activity pH between 4.5 and 6.5; and one or more carboxylic acid; kits and process to obtain this pharmaceutical composition and uses for wounds treatment.
Claims21
1-36. (canceled)
A pharmaceutical composition for topical wound treatment comprising:
- about 0.5 to about 50 mg/ml of a nitrogenous heterocyclic compound of 5 or 6 atoms with imide group;
- about 0.5 to about 40 μg/ml of a deoxyribonuclease enzyme with activity pH between 4.5 and 6.5;
- and
- about 1 to about 15 mg/ml of a carboxylic acid.
A process for producing a pharmaceutical composition, comprising the steps of:
- (a) mixing in a solution a nitrogenous heterocyclic compound of 5 or 6 atoms with imide group and carboxylic acid, thereby forming a mixture;
- (b) adding an alkaline solution dropwise to the mixture until the pH of the mixture is between 4.50 and 6.50, thereby forming a pH-adjusted mixture;
- and
- (c) sterilizing the pH-adjusted mixture;
- (d) adding a deoxyribonuclease enzyme;
- and
- (e) adding a gelling agent.
Dependencies are inferred from the claim text.