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US 2021/0267950 A1Published application
Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
AssigneeGW Research Limited
InventorsGeoffrey GUY, Volker KNAPPERTZ, Eduardo DUNAYEVICH, David CRITCHLEY
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Abstract
The present disclosure provides methods of treating tuberous sclerosis complex comprising administering cannabidiol and everolimus.
Claims17
1-43. (canceled)
A method of treating seizures associated with tuberous sclerosis complex in an everolimus-naive patient, wherein the patient is currently treated with CBD, comprising:
- (a) coadministering everolimus to the patient;
- (b) monitoring the patient's blood plasma concentrations of everolimus;
- and
- (c) if the patient's blood plasma trough concentrations of everolimus exceed 15 ng/mL, then reducing the dose of everolimus by at least 10%.
1 more element
A method of treating seizures associated with tuberous sclerosis complex in an everolimus-naive patient, wherein the patient is currently treated with CBD, comprising:
- (a) administering everolimus to the patient;
- (b) monitoring the patient's blood plasma concentrations of everolimus;
- and
- (c) if the patient's Cmax exceeds 50 ng/mL or AUC0-24 500 h*ng/mL, then reducing the dose of everolimus by at least 10%.
1 more element
Dependencies are inferred from the claim text.