Compositions and methods for treating nafld/nash and related disease phenotypes
AssigneeDuke University
InventorsChristopher B. NEWGARD, Phillip WHITE, Thomas GRENIER-LAROUCHE
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Abstract
The present invention relates to compositions and methods for the treatment of NAFLD. Specifically, the present invention relates to compositions comprising one or more BCDKH agonists and methods of using the same for the treatment of NAFLD.
Claims30
A method for treating metabolic disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of one or more branched-chain ketoacid dehydrogenase complex (BCKDH) agonists.
A method of treating NAFLD in a subject, comprising administering to the subject a therapeutically effective amount of (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid) (BT2).
A composition comprising one or more branched-chain ketoacid dehydrogenase complex (BCKDH) agonists for use in a method of treating metabolic disease in a subject.
A composition comprising (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid) (BT2) for use in a method of treating NAFLD in a subject.
Dependencies are inferred from the claim text.