Compositions and methods for treatment of oral ulceration and oral mucositis
AssigneeCelacare Technologies, LLC
InventorsKenneth M. Yates, Celia A. Proctor, Daniel H. Atchley
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Abstract
An oral rinse including ionic silver as silver citrate complex and acemannan is useful for the treatment of oral ulceration and oral mucositis. The oral rinse has shown effectiveness against fungal and bacteria species such as Candida species, Staphylococcus aureus and Streptococcus pyogenes.
Claims24
An oral rinse for the treatment of oral ulceration and oral mucositis comprising:
- (a) silver citrate complex, wherein the silver citrate complex comprises a concentration of ionic silver of about 10 ppm;
- (b) acemannan, wherein the acemannan has a concentration of about 0.4 w/w %;
- (c) disodium EDTA;
- (d) polyvinylpyrrolidone;
- (e) hyaluronic acid;
- (f) tris(hydroxymethyl)aminomethane, wherein the tris(hydroxymethyl)aminomethane has a concentration sufficient to produce a pH of about 6 to about 6.6 in the oral rinse.
A method for treating oral ulceration and oral mucositis in an oral cavity of a patient, comprising:
- contacting the oral cavity of the patient with an amount of an oral rinse for a period of time, wherein the oral rinse comprises about 3 to about 15 μg/mL silver citrate complex, about 1 to about 10 mg/mL acemannan, disodium EDTA, polyvinylpyrrolidone, hyaluronic acid, and tris(hydroxymethyl)aminomethane.
A method for reducing pain and time to heal in a patient affected by oral ulceration or oral mucositis, comprising:
- contacting the oral cavity of the patient with an amount of an oral rinse for a period of time, wherein the oral rinse comprises about 3 to about 15 μg/mL silver citrate complex, about 1 to about 10 mg/mL acemannan, disodium EDTA, polyvinylpyrrolidone, hyaluronic acid, and tris(hydroxymethyl)aminomethane.
Dependencies are inferred from the claim text.