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US 2021/0267919 A1Published application
Stabilized coated butyrate for colon release
AssigneeBioKier, Inc.
InventorsJerzy Ryszard Szewczyk, Nicolas D. Kirkland, Troy A. Bartron, JR., Abdul Waseh Basit
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Abstract
The present invention relates to coated butyrate and butyrate plus DPP-IV inhibitor tablets. It has been discovered that an inner butyrate core, a first layer neutral polymer which can dissolve in the colon, followed by an outer coating of a composition, which dissolves only in the colon, prevents the interaction of butyrate with these compositions.
Claims11
A tablet of butyrate comprising:
- a) a butyrate core;
- b) the butyrate core coated with a neutral polymer in a thickness from about 5-100 microns;
- and
- c) the neutral polymer coated with a composition that only dissolves in the colon when the tablet is given orally.
1 more element
A method of delivering butyrate to the colon of a patient in need thereof and bypassing the upper digestive tract and stomach comprising:
- a) formulating a butyrate core;
- b) coating the butyrate core with a first layer neutral polymer in a thickness from about 5-100 microns;
- c) coating the core and first layer with a composition that only dissolves in the colon to form a coated tablet;
- and
- d) delivering the coated tablet to the patient.
2 more elements
Dependencies are inferred from the claim text.