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US 2021/0267897 A1Published application
Therapeutic Nanoparticles and Related Compositions, Methods and Systems
AssigneeGenesegues, Inc.
InventorGretchen M. Unger
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Abstract
Disclosed are targeted sub-50 nanometer nanoparticles suitable for delivering bioactive agents of interest, and related compositions, methods, and systems, which improve the manufacturing, stability, efficacy and other aspects of therapeutic nanoparticles.
Claims1
A composition comprising nanoparticles, wherein the nanoparticles comprise:
- at least one bioactive agent, a surfactant having an hydrophile-lipophile balance (HLB) value of less than 6.0 units, a ligand, and Li+ and Cs+, wherein:
- i) the at least one bioactive agent and the surfactant form a surfactant micelle core;
- ii) the ligand forms a shell which substantially coats the nanoparticles;
- and
- iii) the nanoparticles have an average diameter of less than about 50 nanometers.
2 more elements
Dependencies are inferred from the claim text.