Atropine-containing aqueous composition
AssigneesSingapore Health Services Ptel Ltd, Nanyang Technological University, Santen Pharmaceutical Co., Ltd.
InventorsDonald TAN, Roger BEUERMAN, Hiroyuki ASADA, Kyohei TAKAHASHI, Koji SAKANAKA, Takashi MORIMOTO, Toyomi FUJISAWA
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Abstract
Disclosed herein is an aqueous composition comprising 0.001-0.1% (w/v) atropine or a salt thereof, a water-soluble polymer, and buffer (I), which is at a pH range of 6 or lower, wherein the buffer (I) is at least one selected from the group consisting of a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, and trometamol.
Claims33
An aqueous composition comprising 0.001-0.1% (w/v) atropine or a salt thereof, a water-soluble polymer, and buffer (I), wherein the composition has a pH range of 6 or lower, and wherein buffer (I) is selected from the group consisting of a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, trometamol, and a combination thereof.
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A method for maintaining viscosity of an aqueous composition, the method comprising adding a nonionic tonicity agent to the composition, thereby maintaining viscosity of the composition, wherein the composition comprises 0.001-0.1% (w/v) atropine or a salt thereof and a water-soluble polymer, and wherein the composition has a pH range of 6 or lower.
A method for stabilizing atropine or a salt thereof in an aqueous composition, the method comprising adding a nonionic tonicity agent to the composition, thereby stabilizing atropine or a salt thereof in the composition, wherein the composition comprises 0.001-0.1% (w/v) atropine or a salt thereof and a water-soluble polymer, and wherein the composition has a pH range of 6 or lower.
Dependencies are inferred from the claim text.