Generator columns for elution systems loaded with pre-charged matrix
AssigneeJubilant Draximage Inc.
InventorRobert William RIDDOCH
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Abstract
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
Claims20
A generator column for eluting a radioactive solution comprising a desired radioisotope that is generated by the column and an eluant that has eluted through the column, wherein the column is prepared by the following steps:
- a. charging a parent radioisotope on a particulate ion exchange matrix, wherein the parent radioisotope is able to decay into the desired radioisotope;
- and
- b. loading the column with the charged matrix resulting from step (a).
Dependencies are inferred from the claim text.