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US 2021/0261585 A1Published application
Alvocidib Prodrugs Having Increased Bioavailability
AssigneeSumitomo Dainippon Pharma Oncology, Inc.
InventorsAdam Siddiqui-Jain, David J. Bearss
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Abstract
Compounds having the following structure (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein one of R1, R2 or R3 is —P(═O)(OH)2, and the other two of R1, R2 and R3 are each H, are provided. Pharmaceutical compositions comprising the compounds, and methods for use of the compounds for treating diseases associated with overexpression of a cyclin-dependent kinase (CDK) are also provided.
Claims23
A compound having the following structure (I):
- or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein:
- one of R1, R2 or R3 is —P(═O)(OH)2, and the other two of R1, R2 and R3 are each H.
Dependencies are inferred from the claim text.