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US 2021/0260158 A1Published application
Transcription factor-based generation of pacemaker cells and methods of using same
AssigneeCedars-Sinai Medical Center
InventorsEduardo Marban, Hee Cheol Cho
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Abstract
Several embodiments disclosed herein relate generally to methods and compositions for the generation of biological pacemakers. In some embodiments, the methods comprise contacting non-pacemaker cells with one or more transcription factors (in vivo or in vitro) and inducing pacemaker functionality in the cells.
Claims28
1-47. (canceled)
A method of treating a dysfunction in cardiac electrical activity comprising:
- obtaining cells capable of generating a biological pacemaker, wherein the cells are converted from a population of stem cells and/or progenitor cells;
- and
- administering said converted cells to a subject suffering from a dysfunction in cardiac electrical activity, wherein said converted cells exhibit spontaneous, repetitive electrical activity, thereby treating said dysfunction in cardiac electrical activity.
(canceled)
(canceled)
70-76. (canceled)
A method of treating a cardiac arrhythmia by generating a biological pacemaker using transcription factors, comprising:
- identifying a subject suffering from cardiac arrhythmia;
- obtaining a population of converted stem cells and/or progenitor cells,
- wherein, prior to said conversion, said stem cells and/or progenitor cells comprised quiescent cells that did not exhibit spontaneous, repetitive electrical activity;
- wherein one or more of Tbx18, Shox-2, Tbx3, Tbx5, functional fragments thereof, or combinations thereof were administered to said quiescent cells to generate converted cells that exhibit spontaneous, repetitive electrical activity;
- and
- administering said converted cells to said subject, wherein said administered converted cells engraft into the cardiac tissue of said subject and continue to exhibit spontaneous, repetitive electrical activity, thereby generating a biological pacemaker and treating said cardiac arrhythmia.
3 more elements
Dependencies are inferred from the claim text.