Methods of inhibition of protein fucosylation in vivo using fucose analogs

A pharmaceutical composition comprising a therapeutically effective amount of a fucose analog selected from the group consisting of one of the following formulae (V) or (VI):

• or a biologically acceptable salt or solvate thereof, wherein each fucose analog of formula (V) or (VI) can be the alpha or beta anomer or the corresponding aldose form;
• wherein each of R1, R3, and R4 is independently selected from the group consisting of —OH and —OC(O)C1-C10 alkyl;
• and R2 is F, R2a and R3a are each H, and R5 is —CH3.