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AssigneeDermavant Sciences GmbH
InventorsHaripriya KALLURI, Robert LEMING, Piyush JAIN
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Embodiments herein are directed to topical compositions comprising 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid and a combination of one or more of the following components: benzyl alcohol, PEG 400, diisopropyl adipate, diethyl sebacate, dimethyl isosorbide, propylene glycol, 2-(2-ethoxyethoxy)ethanol, hexylene glycol, oleic acid, polysorbate 80, isopropyl myristate, glycerin, DMSO, water, butylated hydroxytoluene, phenoxyethanol, cellulose polymer, Carbomer Homopolymer Type B, and optionally one or more pharmaceutically acceptable topical excipients. The topical compositions may be used to treat a variety of skin conditions.
A topical composition comprising about 0.1% to about 1.0% 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid by weight of the topical composition, about 10.0% to about 50.0% propylene glycol by weight of the topical composition, about 30.0% to about 75.0% 2-(2-ethoxyethoxy)ethanol by weight of the topical composition, about 15.0% to about 50.0% PEG400 by weight of the topical composition, about 0.01% to about 5.0% butylated hydroxytoluene by weight of the topical composition, and optionally one or more pharmaceutically acceptable topical excipients.
3-9. (canceled)
A topical composition comprising about 0.1% to about 1.0% 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid by weight of the topical composition, about 30.0% to about 75.0% 2-(2-ethoxyethoxy)ethanol by weight of the topical composition, about 15.0% to about 65.0% PEG400 by weight of the topical composition, about 5.0% to about 25.0% glycerin by weight of the topical composition, about 0.1% to about 5.0% cellulose polymer(s) by weight of the topical composition, about 0.01% to about 5.0% butylated hydroxy toluene by weight of the topical composition, and optionally one or more pharmaceutically acceptable topical excipients.
14-19. (canceled)
A topical composition comprising about 0.1% to about 1.0% 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid by weight of the topical composition, about 20.0% to about 50.0% propylene glycol by weight of the topical composition, about 25.0% to about 65.0% 2-(2-ethoxyethoxy)ethanol by weight of the topical composition, about 5.0% to about 25.0% glycerin by weight of the topical composition, about 50.0% to about 25.0% dimethyl isosorbide by weight of the topical composition, about 0.01% to about 5.0% butylated hydroxy toluene by weight of the topical composition, and optionally one or more pharmaceutically acceptable topical excipients.
22-28. (canceled)
A topical composition comprising about 0.1% to about 1.0% 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid by weight of the topical composition, about 0.5% to about 5.0% benzyl alcohol by weight of the topical composition, about 1.0% to about 10.0% PEG 400 by weight of the topical composition, about 1.0% to about 20.0% diisopropyl adipate by weight of the topical composition, about 1.0% to about 20.0% diethyl sebacate by weight of the topical composition, about 1.0% to about 20.0% dimethyl isosorbide by weight of the topical composition, about 1.0% to about 30.0% 2-(2-ethoxyethoxy)ethanol by weight of the topical composition, about 1.0% to about 15.0% hexylene glycol by weight of the topical composition, about 1.0% to about 10.0% polysorbate 80 by weight of the topical composition, and optionally one or more pharmaceutically acceptable topical excipients.
32-40. (canceled)
A topical composition comprising about 0.1% to about 1.0% 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)cyclohexyl)acetic acid by weight of the topical composition, about 0.5% to about 5.0% benzyl alcohol by weight of the topical composition, about 30.0% to about 60.0% PEG 400 by weight of the topical composition, about 1.0% to about 30.0% 2-(2-ethoxyethoxy)ethanol by weight of the topical composition, about 1.0% to about 10.0% polysorbate 80 by weight of the topical composition, and optionally one or more pharmaceutically acceptable topical excipients.
42-46. (canceled)
50-59. (canceled)
62-66. (canceled)
69-77. (canceled)
80-88. (canceled)
91-97. (canceled)
Dependencies are inferred from the claim text.