Methods of treatment
AssigneeBow River LLC
InventorsSundar SRINIVASAN, Christina CHOW
Life of this patent
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Abstract
The present disclosure provides for methods of treating a patient with a CYP3A4 substrate drug, wherein the patient is treated with posaconazole. In some embodiments, the patient stops posaconazole treatment, waits for at least 2 days, and then is treated with the CYP3A4 substrate drug as soon as it is safe to do so. In some embodiments, treatment with the CYP3A4 substrate drug is delayed for about 2-42 days after stopping posaconazole. In some embodiments, the patient is treated with a reduced dose of the CYP3A4 substrate drug for about 2-42 days.
Claims26
1-14. (canceled)
A method of treating a cancer with a BRAF V600E or V600K mutation in a patient in need thereof with an antineoplastic drug which is a CYP3A4 substrate, wherein the patient is treated with posaconazole, comprising:
- (a) stopping posaconazole treatment;
- (b) delaying administering, for at least about 3 days after stopping posaconazole treatment, a dose of the anti-neoplastic drug that the patient would have received based on the age and condition of the patient if the patient had not been treated with posaconazole;
- and then
- (c) administering the dose of anti-neoplastic drug.
Dependencies are inferred from the claim text.