Benzopyrazole compounds and analogues thereof

A compound represented by Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein, independently for each occurrence:
• R1 represents substituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl;
• R2 and R3 each independently represent H;
• R4 represents H or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, (heterocycloalkyl)alkyl, aralkyl, heteroaralkyl, hydroxyalkyl, or haloalkyl;
• X represents CH2;
• Y is absent or represents CH2, C(O), CR15R16, S(O)2, or optionally substituted (C3-C7)cycloalkylene, arylene, or heteroarylene;
• Ra represents H or optionally substituted (C1-C6)alkyl, (heterocycloalkyl)alkyl, or (C3-C7)cycloalkyl;
• m is an integer from 1-6;
• n is 0 or 1;
• R15 and R16 are each independently selected from the group consisting of H, hydroxy, halogen, —C(O)OR17, —OR17, —C(O)NR17R18, —NR17R18, alkyl, hydroxyalkyl, haloalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, and (heterocycloalkyl)alkyl, wherein alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, and (heterocycloalkyl)alkyl are optionally substituted with one or more substituents selected from the group consisting of —CN, —OR17, —NR17R18, halo, and alkyl;
• or R15 and R16 may be taken together with the intervening atom to form an optionally substituted carbocyclic or heterocyclic ring;
• R17 and R18 are each independently selected from the group consisting of H, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, and (heterocycloalkyl)alkyl;
• or R17 and R18, when attached to the same atom, may be taken together with the intervening atom to form an optionally substituted heterocyclic ring;
• represents
• Z1 represents N;
• Z2 represents CH;
• Z3 represents C;
• Z4 represents CR8;
• Z5 represents CR5;
• Z6 represents CR6;
• Z7 represents CR9;
• R5 and R6 each independently represent H, halogen, —CN, —NO2, —OR13, —NR13R14, —C(O)R13, —C(O)OR13, —C(O)NR13R14, —OC(O)R13, —NR13C(O)R14, —OC(O)NR13R14, —OC(O)OR13, —NR13C(O)OR14, —NR13C(O)NR13R14, —OS(O)p(R13), —NR13S(O)p(R14), or optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, aralkyl, heteroaralkyl, heteroaryl, aryl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, or (heterocycloalkyl)alkyl;
• L represents —H, —CN, —C(O)R7, —CH(OH)R7, or —S(O)p(alkyl);
• R7, independently for each occurrence, represents H, NH2, CH3, OH, CF3, CH2OH, (C1-C6)alkyl, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, halo(C1-C6)alkyl, NH(C1-C6)alkyl, N((C1-C6)alkyl)2;
• R8 and R9 each independently represent H, halogen, —OR13, —NR13R14, —C(O)R13, —C(O)OR13, —C(O)NR13R14, —OC(O)R13, —NR13C(O)R14, —OC(O)NR13R14, —OC(O)OR13, —NR13C(O)OR14, —NR13C(O)NR13R14, —OS(O)p(R13), —NR13S(O)p(R14), or optionally substituted alkyl, alkenyl, alkynyl, haloalkyl, aralkyl, heteroaralkyl, heteroaryl, or aryl;
• or R5 and R8, or R5 and R6, or R6 and R9 may be taken together with the intervening atoms to form an optionally substituted heterocyclic or carbocyclic ring;
• R13 and R14, independently for each occurrence, represent H or optionally substituted alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, (cycloalkyl)alkyl, heterocycloalkyl, or (heterocycloalkyl)alkyl;
• or, when R13 and R14 are attached to the same atom, R13 and R14 taken together with the atom may form an optionally substituted heterocyclic ring;
• and
• p is 0, 1, or 2.