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US 2021/0259977 A1Published application
Pharmaceutical compositions comprising a thyroid hormone beta agonist, method of use and method making thereof
AssigneeGannex Pharma Co., Ltd.
InventorsJinzi Jason WU, Xuyu CHAI
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Abstract
A pharmaceutical formulation contains the following components in part by weight: (a) 1 part of the compound represented by Formula (I), (b) 16 to 600 parts of a meltable and dispersible carrier comprising poloxamer and polyethylene glycol in a poloxamer-to-polyethylene glycol weight ratio of 1-0.5 to 1:27, and (c) 0.2 to 100 parts of a non-volatile weak acid. The pharmaceutical formulation helps to improve the in vitro dissolution of the compound of Formula (I).
Claims20
A pharmaceutical composition, comprising the following components in parts by weight,:
- (a) 1 part of a compound of Formula (I);
- (b) 16 to 600 parts of a meltable and dispersible carrier comprising poloxamer and polyethylene glycol with a poloxamer:
- polyethylene glycol weight ratio in the range of 1:0.5 to 1:27;
- and
- (c) 0.2 parts to 100 parts of a non-volatile weak acid.
2 more elements
Dependencies are inferred from the claim text.