Methods and compositions for localized agent delivery
AssigneeMassachusetts Institute of Technology
InventorsDarrell J. IRVINE, Matthias STEPHAN, Jaehyun MOON, Anna BERSHTEYN
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Abstract
The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
Claims20
A biodegradable nanoparticle comprising maleimide groups on its exterior surface.
A method for delivering an agent comprising administering to a subject a nucleated cell bound to a nanoparticle that comprises an agent, wherein the agent is released from the particle in vivo.
Dependencies are inferred from the claim text.