Formulation containing emricasan
AssigneeThe Doshisha
InventorsNoriko Koizumi, Naoki Okumura
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Abstract
The present disclosure provides a formulation having improved solubility and/or stability of emricasan. In one embodiment, the present disclosure provides a formulation containing (i) emricasan or a derivative thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, (ii) a nonionic surfactant including a polyoxyethylene group, and (iii) a buffering agent that maintains the pH at about 4.5 to about 8.5. The present disclosure also provides a composition in the form of powder for preparing such a formulation at the time of use.
Claims20
A formulation comprising:
- (i) emricasan or a derivative thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof;
- (ii) a nonionic surfactant comprising a polyoxyethylene group;
- and
- (iii) a buffering agent that maintains pH at about 3.0 to about 8.5.
A formulation comprising emricasan, wherein the formulation comprises:
- (i) emricasan that is present in the formulation at about 0.1% by weight to about 1% by weight;
- (ii) a surfactant selected from the group consisting of HCO-20, HCO-40, HCO-60, HCO-80, HCO-100, CO-35, MYS-40, Tween 80, and poloxamer 407, the surfactant being present in the formulation at about 0.1% by weight to about 4% by weight;
- and
- (iii) a buffering agent that maintains pH at about 3.0 to about 8.0.
-48. (canceled)
Dependencies are inferred from the claim text.