Computational simulation platform for planning of interventional procedures

A system for simulation and planning of interventional procedures, comprising:

• one or more medical imaging devices;
• one or more computer systems communicatively coupled to the one or more medical imaging devices, the one or more computer systems being configured to:
• generate a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging data received from the one or more medical imaging devices;
• assign material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging data received from the one or more medical imaging devices, wherein the assigning of the material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging data includes:
• determining wall or plaque thickness, lumen area, plaque eccentricity and plaque constituents based on the invasive or non-invasive imaging;
• dividing the vessel lumen into sequential zones of plaque material;
• and assigning a value ranging from purely calcium plaque material to purely lipid plaque material;
• import design and material properties of stents and balloons;
• generate a mesh or meshless model of a stent and balloon based on the imported design and material properties;
• position the modeled stent and balloon within the 3D reconstructed vessel lumen;
• perform balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen;
• and
• assess stent and vessel morphometric and biomechanical measures based on the computational simulations.

A computational simulation platform for interventional procedures planning, comprising a computer-implemented method that includes:

• generating a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging;
• assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging, wherein the assigning of the material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging includes:
• determining wall or plaque thickness, lumen area, plaque eccentricity and plaque constituents based on the invasive or non-invasive imaging;
• dividing the vessel lumen into sequential zones of plaque material;
• and assigning a value ranging from purely calcium plaque material to purely lipid plaque material;
• performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen;
• and
• assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.