US 2021/0242004 A1Published application

Imaging mass spectrometry data processing device

AssigneeShimadzu Corporation

InventorShinichi YAMAGUCHI

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Abstract

A peak-waveform conversion processor detects a peak in a profile spectrum created based on data obtained at each measurement point in a sample's measurement area, and acquires a rod-like peak by performing centroid conversion processing on a waveform of the peak having a mountain shape. When an operator specifies a target compound to be observed, a mass difference calculation unit calculates a mass difference between a precise m/z of the target compound and an m/z of a rod-like peak at a position close to the precise m/z for each measurement point. A mass difference image creator creates an image showing a distribution of mass differences based on the calculated mass differences. A mass difference related information calculation unit acquires an index value such as an average value of a plurality of mass differences for each mass difference image, and creates a graph showing a frequency distribution of the mass differences.

Claims3

Dependent claims

An imaging mass spectrometry data processing device configured to process mass spectrometry data which is profile data obtained from a plurality of micro areas in a measurement area on a sample, the imaging mass spectrometry data processing device comprising:

a) an input reception unit configured to receive a specification by a user of a compound or a mass-to-charge ratio value to be displayed in a mass spectrometry image;
b) a mass difference calculation unit configured to calculate a difference, for each micro area, between a mass-to-charge ratio value corresponding to a compound specified by the user or a target mass-to-charge ratio value which is a mass-to-charge ratio value specified by the user, and an observed mass-to-charge ratio value which is acquired from a peak observed in a profile spectrum formed using the profile data and which is inferred to correspond to the target mass-to-charge ratio value, and
c) a mass difference image creator configured to create and display an image showing a two-dimensional distribution of mass differences corresponding to the measurement area or a part of the measurement area based on information on the mass difference calculated by the mass difference calculation unit for each micro area.

Dependencies are inferred from the claim text.