A computer-implemented method of generating a risk assessment of coronary disease of a subject based on image analysis of a non-invasive medical image of the subject and compound quantification analysis of plaque, stenosis, ischemia, and fat parameters derived from the image analysis, the method comprising:
- accessing, by a computer system, a medical image of a coronary region of a subject, wherein the medical image of the coronary region of the subject is obtained non-invasively;
- identifying, by the computer system utilizing a coronary artery identification algorithm, one or more coronary arteries in the medical image of the coronary region of the subject;
- identifying, by the computer system utilizing a plaque identification algorithm, one or more regions of plaque within the one or more coronary arteries identified from the medical image of the coronary region of the subject;
- identifying, by the computer system utilizing a fat identification algorithm, one or more regions of fat in the medical image of the coronary region of the subject;
- determining, by the computer system, one or more vascular morphology parameters and a set of quantified plaque parameters of the one or more identified regions of plaque based at least in part on analysis of the medical image of the coronary region of the subject, wherein the set of quantified plaque parameters comprises a ratio or function of volume or surface area, heterogeneity index, geometry, and radiodensity of the one or more regions of plaque in the medical image;
- quantifying, by the computer system, coronary stenosis or luminal narrowing based at least in part on the one or more vascular morphology parameters and the set of quantified plaque parameters determined from the medical image of the coronary region of the subject;
- and
- determining, by the computer system, a presence or risk of ischemia based at least in part on the one or more vascular morphology parameters and the set of quantified plaque parameters determined from the medical image of the coronary region of the subject;
- determining, by the computer system, a set of quantified fat parameters of the one or more identified regions of fat within the medical image of the coronary region of the subject, wherein the set of quantified fat parameters comprises volume, geometry, and radiodensity of the one or more regions of fat in the medical image;
- generating, by the computer system, a weighted measure of the determined one or more vascular morphology parameters, set of quantified plaque parameters of the one or more regions of plaque, quantified coronary stenosis, presence or risk of ischemia, and set of quantified fat parameters;
- and
- generating, by the computer system, a risk assessment of coronary disease of the subject based at least in part on the generated weighted measure of the determined one or more vascular morphology parameters, set of quantified plaque parameters of the one or more regions of plaque, quantified coronary stenosis, presence or risk of ischemia, and set of quantified fat parameters,
- wherein the computer system comprises a computer processor and an electronic storage medium.