Identification of ligands and their use
AssigneeOxford University Innovation Limited
InventorsGraham Ogg, Li-Chieh Huang, Aamir Aslam
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Abstract
The invention provides carriers and kits for use in the identification of ligands. Carriers of the invention are provided to which is attached a DNA encoding a peptide and a β2 microglobulin. Carriers of the invention are capable of identifying an epitope recognized by a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor. The invention also provides kits for screening for a T-cell epitope and/or an NK-cell epitope and/or an NKT-cell epitope, wherein the kits comprise a carrier of the invention.
Claims12
A carrier to which is attached a peptide, DNA encoding the peptide, and β2 microglobulin.
A carrier to which is attached a peptide, DNA encoding the peptide, and β2 microglobulin and/or an MHC or MHC-like molecule.
A kit for screening for a T-cell epitope and/or an NK-cell epitope and/or an NKT-cell epitope, wherein the kit comprises a carrier to which is attached a peptide, DNA encoding the peptide and β2 microglobulin.
Dependencies are inferred from the claim text.