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US 2021/0239685 A1Published application
Methods of analyzing dna in urine
AssigneeThe Trustees of Indiana University
InventorTim LAUTENSCHLAEGER
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Abstract
The present disclosure relates to methods of extracting DNA from urine and methods of analyzing DNA in a urine sample. Methods are provided for extracting ctDNA from a urine sample and analyzing the extracted ctDNA for mutations indicative of a disease. The disclosure also relates to compositions for use in such methods.
Claims20
A method of detecting or monitoring circulating tumor DNA (ctDNA) in a patient urine sample comprising:
- i. processing a patient urine sample to concentrate the sample;
- ii. extracting the ctDNA from the sample;
- and
- iii. analyzing the ctDNA in the sample wherein the ctDNA comprises short DNA fragment of less than 100 base pair (bp) in length.
1 more element
Dependencies are inferred from the claim text.