Leukocyte recruitment in infectious disease
AssigneeStickycell Pty Ltd
InventorsQiang Cheng, Anqi Li, Karina Islas Rios, Erick Vargas-Ordaz
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Abstract
The present disclosure relates to assays, including but not limited to, leukocyte adhesive function assays (LAFA), devices and/or methods of using such assays. The present disclosure also relates to the uses of the disclosed embodiment in diagnostic, analytic and/or prognostic applications, particularly for diagnostic, analytic and/or prognostic applications in relation to diseases associated with abnormal host immune responses.
Claims24
A method to discriminate between an infectious and non-infectious inflammatory immune response in a subject, the method comprising:
- subjecting a blood sample from the subject to at least one leukocyte function assay (LAFA), wherein the LAFA assesses leukocyte recruitment, adhesion and/or migration to at least one endothelial cell molecule;
- and
- based at least in part on one or more results of the at least one LAFA, determine whether the subject has an infectious inflammatory immune response or a non-infectious inflammatory immune response.
(canceled)
(canceled)
The method of claim 8, wherein the results of the at least one LAFA from at least one healthy blood sample is used as a reference level for generating one or more parameters that are used of generating one or more indexes.
-17. (canceled)
A method to assess a subject's response, or potential response, to a drug suitable for treating an infectious disease, the method comprising:
- subjecting a blood sample from the subject to at least one leukocyte function assay (LAFA), wherein the LAFA assesses leukocyte recruitment, adhesion and/or migration to at least one endothelial cell molecule;
- and
- based at least in part on one or more results of the at least one LAFA, assess a patient's response, or potential response, to the drug for treating the infectious disease.
A method of detecting a subset of leukocytes in a subject having an inflammatory immune response, the method comprising subjecting a blood sample from the subject to at least one leukocyte function assay (LAFA), wherein the LAFA assesses leukocyte recruitment, adhesion and/or migration to at least one endothelial cell molecule;
- detecting one or more leukocyte cell surface markers, and
- based at least in part on one or more results of the at least one LAFA and detection of one or more leukocyte cell surface markers, determining a subset of leukocytes associated with the inflammatory immune response.
-50. (canceled)
Dependencies are inferred from the claim text.