Apparatus, Method, and Computer Program Product for Adapting a Predefined Liquid Chromatography Process

A method for manufacturing a column for a liquid chromatography system, the column having an inlet and an outlet and comprises a vessel for holding a resin, wherein the method comprises:

• selecting a type of column configured to be used in a process for purification of a sample comprising a target product,
• selecting the resin based on the type of column, the resin having media properties
• selecting the vessel for holding the resin, the vessel having hardware properties,
• packing the resin to form a resin bed in the vessel using a pressure based on the type of column to establish a height of the resin bed,
• determining production parameters based on the media properties and the hardware properties to define column data for the column, and
• storing the column data in a data storage, which is accessible for the liquid chromatography system.

A method for controlling a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process, wherein the method comprises:

• controlling the operation of the chromatography system to run the predefined process,
• retrieving column data accessible from a data storage, the column data being specific to each column, and
• adapting at least one process parameter of the predefined process for each column based on column data,
• whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.