Fusion protein
AssigneeLevicept LTD
InventorSimon WESTBROOK
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Abstract
The present invention relates to a p75NTR neurotrophin binding protein (NBP)-Fc fusion protein comprising a p75NTR(NBP) portion and an immunoglobulin portion. In certain embodiments, the p75NTR(NBP)-Fc fusion protein is for use in the treatment of pain and/or a symptom of pain.
Claims18
A p75NTR neurotrophin binding protein (NBP)-Fc fusion protein, comprising:
- (a) a p75NTR(NBP) portion;
- and
- (b) an immunoglobulin Fc portion.
The p75NTR(NBP)-Fc fusion protein according to any preceding claim, comprising or consisting of the amino acid sequence set forth in SEQ ID NO:3.
The p75NTR(NBP)-Fc fusion protein according to any preceding claim wherein the p75NTR(NBP) binds to any of NGF, BDNF, NT3 or NT4/5 with a binding affinity (Kd) of between about 0.01 nM to about 50 nM as measured by surface plasmon resonance at 20° C.
The p75NTR(NBP)-Fc fusion protein according to any preceding claim for use in the treatment of pain or a symptom of pain.
Dependencies are inferred from the claim text.