Treatment Determination and Impact Analysis

An article of manufacture including a non-transitory computer-readable medium, having stored thereon program instructions that, upon execution by a computing device, cause the computing device to perform operations comprising:

• discovering, via processor-based statistical testing on a first attribute profile database, a set of core single nucleotide polymorphism (SNP) attributes that are statistically associated above a first threshold with a non-monogenic health attribute, wherein the first attribute profile database is associated with a population of individuals and contains SNP attributes and behavioral phenotype attributes;
• discovering, via processor-based statistical testing on the first attribute profile database, a set of behavioral phenotype attributes that are statistically associated above a second threshold with the non-monogenic health attribute and statistically associated above a third threshold with the set of core SNP attributes;
• receiving a query that is representative of the non-monogenic health attribute with respect to an individual;
• accessing a second attribute profile database associated with the individual, the second attribute profile database comprising SNP attributes and behavioral phenotype attributes associated with the individual;
• calculating, based on the second attribute profile database, a genetic risk associated with the non-monogenic health attribute, wherein the genetic risk is determined at least in part based on a degree of overlap between the SNP attributes of the individual and the set of core SNP attributes;
• identifying, based on the genetic risk, a reportable set of behavioral phenotype attributes from the set of behavioral phenotype attributes that are statistically associated above a fourth threshold with the non-monogenic health attribute, wherein the reportable set of behavioral phenotype attributes indicate behaviors that, when modified, have an observable statistical correlation with a propensity of the individual to exhibit a non-monogenic health condition associated with the non-monogenic health attribute;
• and
• transmitting, in response to the query, the reportable set of behavioral phenotype attributes as modifiable attributes related to the non-monogenic health condition.

A computer-implemented method comprising:

• receiving a query that is representative of a non-monogenic health attribute with respect to an individual, wherein a set of core single nucleotide polymorphism (SNP) attributes are statistically associated above a first threshold with the non-monogenic health attribute, and wherein a set of behavioral phenotype attributes are statistically associated above a second threshold with the non-monogenic health attribute and statistically associated above a third threshold with the set of core SNP attributes;
• accessing an attribute profile database associated with the individual, the attribute profile database comprising SNP attributes and behavioral phenotype attributes associated with the individual;
• calculating, based on the attribute profile database, a genetic risk associated with the non-monogenic health attribute, wherein the genetic risk is determined at least in part based on a degree of overlap between the SNP attributes of the individual and the set of core SNP attributes;
• identifying, based on the genetic risk, a reportable set of behavioral phenotype attributes from the set of behavioral phenotype attributes that are statistically associated above a fourth threshold with the non-monogenic health attribute;
• and
• transmitting, in response to the query, the reportable set of behavioral phenotype attributes as modifiable attributes related to a non-monogenic health condition associated with the non-monogenic health attribute.