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US 2021/0231677 A1Published application
Traceless immobilization of analytes for samdi mass spectrometry
AssigneeNorthwestern University
InventorsMilan Mrksich, Kazi Y. Helal
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Abstract
The present disclosure is directed to materials and methods of high throughput, traceless immobilization of analytes for use in self-assembled monolayer for matrix-assisted laser desorption and ionization (SAMDI) mass spectrometry. Methods of the disclosure are useful, in various embodiments, for measuring the activity of an enzyme or for monitoring a chemical reaction.
Claims36
A self-assembled monolayer-substrate composition, comprising:
- a self-assembled monolayer (SAM) attached to at least a portion of the substrate surface, wherein the SAM comprises an alkyl chain having a reactive group at one terminus for association with the substrate surface and at least a portion of the SAM further comprising a traceless linker that is capable of reacting with an analyte upon exposure to ultraviolet light.
Dependencies are inferred from the claim text.