US 2021/0231653 A1 · MICROFLUIDIC CHIP, LIQUID SAMPLE DETECTION DEVICE AND METHOD

Abstract

A microfluidic chip, a liquid sample detection device and a liquid sample detection method are provided. The microfluidic chip includes: a liquid inlet; a waste tank; an accommodating chamber respectively communicated with the liquid inlet and the waste tank at two ends of the accommodating chamber; and at least one giant magnetoresistance structure attached to a wall of the accommodating chamber and having a marker attached thereto. The giant magnetoresistance structure is configured to be attached with magnetic bead particles combined with a to-be-detected object in a liquid sample through a combination of the to-be-detected object and the marker.

Claims19

Dependent claims

A microfluidic chip, comprising:

a liquid inlet;
a waste tank;
an accommodating chamber, respectively communicated with the liquid inlet and the waste tank at two ends of the accommodating chamber;
and
at least one giant magnetoresistance structure attached to a wall of the accommodating chamber and having a marker attached thereto, wherein
the giant magnetoresistance structure is configured to be attached with magnetic bead particles combined with a to-be-detected object in a liquid sample through a combination of the to-be-detected object and the marker.

3 more elements

A method for detecting a liquid sample, comprising:

mixing a liquid sample with magnetic bead particles to combine a to-be-detected object in the liquid sample with the magnetic bead particles;
causing the liquid sample to be in contact with a giant magnetoresistance structure to which a marker is attached, such that the magnetic bead particles are attached to the giant magnetoresistance structure through a combination of the to-be-detected object and the marker;
applying a first magnetic field to the giant magnetoresistance structure;
and
detecting resistance of the giant magnetoresistance structure under the function of the first magnetic field, so as to obtain a number of the magnetic bead particles attached to the giant magnetoresistance structure and determine a content of the to-be-detected object in the liquid sample.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/964,449Filed 24 Feb 2020

Priority

CN 201910261840.62 Apr 2019

Published

29 Jul 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

G01N 33/54373
Apparatus specially adapted for solid-phase testing: involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/502761
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
G01N 27/745
Of fluids: for detecting magnetic beads used in biochemical assays

Microfluidic chip, liquid sample detection device and method

Life of this patent

Microfluidic chip, liquid sample detection device and method

Life of this patent

Abstract

Claims19