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AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsThomas F. MEYER, Mirjana KESSLER
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The present invention relates to a method for the production of a culture, e.g. an organoid culture of ovarian cancer or cancer precursor cells, particularly of high grade serous ovarian carcinoma cells. By means of this method, an organoid culture of ovarian cancer or cancer precursor cells and a biobank comprising a plurality of different organoid cultures of ovarian cancer or cancer precursor cells may be generated. Further, a culture medium suitable for the long-term culture of ovarian cancer or cancer precursor cells is provided. Furthermore, use of the organoid culture and the biobank for medical applications, e.g. in the field of diagnostics, and therapy and in the field of drug screening is described.
A method for the production of an ovarian cancer or cancer precursor cell culture, said method comprising the steps:
An ovarian cancer or cancer precursor cell organoid culture which can be stably propagated.
Use of a cell culture medium which comprises at least one compound which stimulates BMP signaling, e.g. via BMP2, for the production of a culture, e.g. an organoid culture, from ovarian cancer or cancer precursor cells, wherein the cell culture medium is free of Noggin.
Dependencies are inferred from the claim text.