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US 2021/0230551 A1Published application
Enhancement of fibroblast plasticity for treatment of disc degeneration
AssigneeSpinalCyte, LLC
InventorsPete O'Heeron, Thomas Ichim
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Abstract
Embodiments of the disclosure include methods and compositions related to preparation of fibroblasts for use of treatment and prevention of a degenerative disc in an individual. In particular cases, fibroblasts are subject to de-differentiation that results in enhancement of their therapeutic activity and such methods include exposure of the fibroblasts to one or more agents and/or conditions.
Claims18
A method of preparing fibroblasts for use in treatment of a degenerative disc in an individual, comprising the step of exposing fibroblasts to one or more of the following de-differentiation agents:
- a) one or more histone deacetylase inhibitors;
- b) one or more DNA methyltransferase inhibitors;
- c) umbilical cord blood serum;
- d) one or more GSK-3 inhibitors;
- and/or
- e) one or more components from donor cells.
3 more elements
Dependencies are inferred from the claim text.