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US 2021/0230159 A1Published application
4h-pyrido[1,2-a]pyrimidin-4-one compounds
AssigneePrana Biotechnology Limited
InventorsPenelope Jane Huggins, Jack Gordon Parsons, Kevin Jeffrey Barnham, Elisabeth Colette Louise Gautier, Antony Vincent Robinson
Life of this patent
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Abstract
The present invention relates to compounds of the formula I or II: (I) (II) processes for their preparation and their use as pharmaceutical agents or compositions in the treatment, of neurological disorders.
Claims10
A compound of formula Ic:
- in which
- R2 is (CH2)nNR9R10,
- R5 is H or C1-4 alkyl;
- R6 is H or halo;
- provided that one of R5 and R6 is not hydrogen;
- R8 is H, C1-4 alkyl or (CH2)n aryl;
- and
- R9 and R10 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclyl in which the heterocyclyl group is optionally substituted with a C1-4 alkyl aryl group in which the aryl group may be optionally substituted with one or two substituents selected from C1-6alkyl, halo, CF3, hydroxy, C1-6 alkoxy or OCF3;
- n is 0, 1, 2 or 3;
- each 5 or 6 membered heterocyclyl group may have 1, 2, 3 or 4 heteroatoms selected from O, S and N and may be saturated, unsaturated or aromatic;
- or a pharmaceutically acceptable salt, stereoisomer or geometric isomer thereof.
8 more elements
A compound of formula II
- in which
- R2 is (CH2)nNR9R10,
- R5 is H or C1-4 alkyl;
- R6 is H or halo;
- provided that one of R5 and R6 is not hydrogen;
- R8 is H, C1-4 alkyl or (CH2)n aryl;
- and
- R9 and R10 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclyl in which the heterocyclyl group is optionally substituted with a C1-4 alkyl aryl group in which the aryl group may be optionally substituted with one or two substituents selected from C1-6alkyl, halo, CF3, hydroxy, C1-6 alkoxy or OCF3;
- n is 0, 1, 2 or 3;
- each 5 or 6 membered heterocyclyl group may have 1, 2, 3 or 4 heteroatoms selected from O, S and N and may be saturated, unsaturated or aromatic;
- or a pharmaceutically acceptable salt, stereoisomer or geometric isomer thereof;
- and
- M is transition metal.
10 more elements
Dependencies are inferred from the claim text.