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US 2021/0230139 A1Published application
Monoamine oxidase b imaging probe
AssigneeTohoku University
InventorsRyuichi HARADA, Shozo FURUMOTO, Yukitsuka KUDO, Nobuyuki OKAMURA
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Abstract
The present invention provides a compound represented by formula (I) that can image monoamine oxidase-B with high specificity and selectivity for monoamine oxidase-B and with good sensitivity, or a pharmaceutically acceptable salt or solvate thereof.
Claims17
A compound represented by formula (I):
- [wherein
- A represents a cyclic group represented by formula:
- a cycle A may be a non-substituted group, or may be optionally substituted with one or more R5 group, and each R5 represents independently of each other a C1-C6 alkyl group or a C3-C6 cycloalkyl group;
- R1 group represents a C1-C6 alkyl group or a C3-C6 cycloalkyl group;
- Z represents a group represented by formula:
- wherein
- R2 represents a halogen atom,
- R3 represents a hydroxy group,
- each R6 represents independently of each other a C1-C6 alkyl group, or a C3-C6 cycloalkyl group,
- o is an integer of 0 to 1,
- p is an integer of 0 to 1,
- q is an integer of 0 to 2;
- R4 each represents independently of each other a C1-C6 alkyl group or a C3-C6 cycloalkyl group;
- m is an integer of 0 to 3;
- n is an integer of 0 to 5;
- and
- each line that the above dotted line intersects with represents a bond to the other structural moiety of the above formula (I),
- or a pharmaceutically acceptable salt or solvate thereof.
15 more elements
Dependencies are inferred from the claim text.