Method for separation of methionine sulfoxide diastereomers
AssigneesThe Regents of the University of California, Caltech
InventorsJevgenij Raskatov, Scott C. Virgil
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Abstract
A method of separating a compound having methionine oxide diastereomers, including: loading a diastereomeric mixture into a chromatography column, the diastereomeric mixture of a compound having a plurality of methionine oxide diastereoisomers. The method also includes passing a mobile phase, the mobile phase including a supercritical fluid, through the chromatography column to separate the compound based on each methionine oxide diastereoisomer of the plurality of methionine oxide diastereoisomers in the chromatography column.
Claims19
A method for producing a diasteriomerically pure methionine sulfoxide composition, the method comprising:
- loading a diastereomeric mixture of compositions that contain at least one of S-methionine sulfoxide (Met-(S)-SO) or R-methionine sulfoxide (Met-(R)-SO) onto a chromatography column;
- and
- passing a mobile phase, the mobile phase including a supercritical fluid, through the chromatography column to separate compositions that contain Met-(S)-SO from those that contain Met-(R)-SO using the chromatography column, thereby producing a diastereomerically pure methionine sulfoxide composition.
A methionine sulfoxide (MetSO) composition comprising at least 60% Met-(R)-SO relative to Met-(S)-SO or comprising at least 60% Met-(S)-SO to Met-(R)-SO.
An Aβ42 composition comprising MetSO at position 38, the Aβ42 composition comprising at least 60% Met-(R)-SO relative to Met-(S)-SO or at least 60% Met-(S)-SO relative to Met-(R)-SO at amino acid 38.
Dependencies are inferred from the claim text.