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US 2021/0228778 A1Published application
Porous composite material
AssigneeTampereen KorkeakoulusääTiö Sr
InventorsKaarlo Paakinaho, Minna Kellomäki
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Abstract
The present invention relates to porous composite materials and objects such as 3D scaffolds, in particular to bioactive and bioresorbable scaffolds that can be transformed at body temperature.
Claims24
A method for producing porous composite material, the method comprising.
- (A) providing porous composite material comprising biodegradable and bioabsorbable organic polymer and bioactive particles dispersed therein, wherein overall porosity of the composite material is 60-80%, average pore size is 200-500 μm, content of the bioactive particles in the composite material is 50-80% by weight, wherein the bioabsorbable organic polymer comprises caprolactone, the bioactive particles are selected from bioceramic particles and bioactive glass particles, and wherein at least 50% of pores of the composite material are connected to each other by channels, wherein width of the channels is at least 5 μm, and wherein the method further comprises
- (I) immersing the porous composite material into a fluid and/or heating at 25-40 C.°,
- (II) squeezing the porous composite material by subjecting the porous composite material to an external force, and
- (III) releasing the external force.
1 more element
A method for producing porous composite material, the method comprising
- (A) melt mixing biodegradable and bioabsorbable organic polymer and bioactive particles dispersed therein to produce a composite material, wherein content of the bioactive particles in the composite material is 50-80% by weight, and wherein the bioabsorbable organic polymer comprises caprolactone, and the bioactive particles are selected from bioceramic particles and bioactive glass particles,
- (B) forming one or more holes to the composite material,
- (C) optionally filling one or more of the one or more holes with bioactive particles selected from bioceramic particles, bioactive glass particles and mixtures thereof,
- wherein the method further comprises, for producing the porous composite material,
- (D) saturating the composite material with CO2 under conditions wherein CO2 pressure is at least 74 bar and temperature is between 31° C. and melting temperature of crystalline phase of the organic polymer, and
- (E) decreasing the CO2 pressure to 1 bar, and keeping temperature between 31° C. and melting temperature of crystalline phase of the organic polymer, and
- wherein the method further comprises:
- (I) immersing the porous composite material into a fluid and/or heating at 25-40 C.°,
- (II) squeezing the porous composite material by subjecting to an external force, and
- (III) releasing the external force.
7 more elements
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Dependencies are inferred from the claim text.