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US 2021/0228746 A1Published application
Affinity Magnetic Particles For Imaging System
AssigneeBoard of Trustees of Michigan State University
InventorsErik M. SHAPIRO, Shatadru CHAKRAVARTY
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Abstract
A nanoparticle construct is provided. The nanoparticle construct includes a nanoparticle defining an outer surface, a magnetic nanocrystal carried by the nanoparticle, and a coupling agent extending from the outer surface of the nanoparticle. The coupling agent is configured to couple the nanoparticle construct to a cell.
Claims20
A nanoparticle construct comprising:
- a nanoparticle defining an outer surface;
- a magnetic nanocrystal carried by the nanoparticle;
- and
- a coupling agent extending from the outer surface of the nanoparticle,
- wherein the coupling agent is configured to couple the nanoparticle construct to a cell.
2 more elements
A method of treating a subject in need thereof, the method comprising:
- subjecting the subject, or having the subject subjected to, a treatment comprising:
- isolating a cell from the subject;
- modifying the cell to generate a therapeutic cell;
- coupling the therapeutic cell to a nanoparticle construct to form a magnetic therapeutic cell, the nanoparticle construct comprising:
- a nanoparticle defining an outer surface;
- a magnetic nanocrystal carried by the nanoparticle;
- and
- a coupling agent extending from the outer surface of the nanoparticle,
- wherein the coupling agent is configured to couple the nanoparticle construct to the therapeutic cell;
- and
- administering the magnetic therapeutic cell to the subject;
- performing magnetic resonance imaging (MRI) or magnetic particle imaging (MPI) on the subject;
- determining the location of the magnetic therapeutic cell based on a MRI image or a MPI image;
- and
- when the location of the magnetic therapeutic cell is determined to be at a location needing the therapeutic cell, continuing the treatment;
- or
- when the location of the magnetic therapeutic cell is determined to be at a location other than a location needing the therapeutic cell, discontinuing the treatment.
14 more elements
A method of treating a subject in need thereof, the method comprising:
- performing magnetic resonance imaging (MRI) or magnetic particle imaging (MPI) on the subject, wherein the subject is undergoing a treatment in which:
- a cell was isolated from the subject;
- the cell was modified to generate a therapeutic cell;
- the therapeutic cell was coupled to a nanoparticle construct to form a magnetic therapeutic cell, the nanoparticle construct comprising:
- a nanoparticle defining an outer surface;
- a magnetic nanocrystal carried by the nanoparticle;
- and
- a coupling agent extending from the outer surface of the nanoparticle and bonded to the therapeutic cell;
- and
- the magnetic therapeutic cell was administered to the subject;
- determining the location of the magnetic therapeutic cell based on a MRI image or a MPI image;
- and
- when the location of the magnetic therapeutic cell is determined to be at a location needing the therapeutic cell, continuing the treatment;
- or
- when the location of the magnetic therapeutic cell is determined to be at a location other than a location needing the therapeutic cell, discontinuing the treatment.
12 more elements
Dependencies are inferred from the claim text.