Methods and compositions for theranostic nanoparticles
AssigneesUniversity of Central Florida Research Foundation, Inc., Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Memorial Sloan Kettering Cancer Center
InventorsAnnette Khaled, Jesus Manuel Perez Figueroa, Santimukul Santra, Charalambos Kaittanis, Oscar Santiesteban, Jan Grimm, Hampton Sessions
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Abstract
Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.
Claims134
A method of identifying a solid tumor cell target, comprising, 1) contacting a cell with an effective amount of a composition comprising at least one nanoparticle conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein, wherein the nanoparticle further comprises an imaging compound;
- 2) identifying one or more nanoparticles bound to the cells by using imaging devices;
- and optionally, 3) monitoring the solid tumor cell target by repeating 1) and 2).
A cancer therapeutic composition, comprising:
- at least one nanoparticle conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein, wherein the nanoparticle further comprises an imaging compound and having a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle.
A method for treating cancer, comprising:
- a) administering to a subject diagnosed with prostate cancer an effective amount of a nanoparticle composition comprising, at least one nanoparticle conjugated with targeting ligand that is a substrate for a solid tumor-specific cell protein, wherein the nanoparticle further comprises an imaging compound and has a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle.
A nanoparticle, comprising:
- a polymeric nanoparticle conjugated with targeting ligand that is a substrate for a solid tumor-specific cell protein, wherein the nanoparticle further comprises one or more imaging compounds and/or one or more therapeutic agents encapsulated in the hydrophobic interior of the nanoparticle.
A nanoparticle comprising a hyperbranched hyperbranched polyester functionalized with azide groups.
A cancer therapeutic composition, comprising:
- at least one nanoparticle conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein, wherein the nanoparticle further comprises one or more therapeutic agents encapsulated in the hydrophobic interior of the nanoparticle.
Dependencies are inferred from the claim text.