Serum Albumin-Binding Fibronectin Type III Domains
AssigneeJanssen Biotech, Inc.
InventorsMichael Diem, Steven Jacobs, Karyn O'Neil, Thomas Rutkoski
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Abstract
Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.
Claims14
1-16. (canceled)
A protein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:
- 53 or an amino acid sequence having 1, 2, 3, 4, 5, 6, 7, or 8 substitutions as compared to the amino acid sequence of SEQ ID NO:
- 53.
A protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 53.
Dependencies are inferred from the claim text.