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US 2021/0228681 A1Published application
Compositions and methods for treating glioblastoma
AssigneeTel HaShomer Medical Research Infrastructure and Services Ltd.
InventorsJoab CHAPMAN, Efrat SHAVIT-STEIN
Life of this patent
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Abstract
Compositions and methods for treating malignant gliomas such as glioblastoma are provided, comprising a combination of a peptide conjugate comprising an amino acid sequence derived from the N-terminus of the receptor PAR-1, and the chemotherapeutic agent temozolomide.
Claims21
-25. (canceled)
A method for treating malignant glioma in a subject in need thereof, the method comprising administering to the subject a peptide conjugate having the following general formula:
- α-amino protecting moiety-PAR-1 peptide-protease-disabling moiety, wherein the PAR-1 peptide is selected from the group consisting of Asp-Pro-Arg and SEQ ID NOs:1-17, and administering temozolomide the said subject.
Dependencies are inferred from the claim text.