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AssigneesABT Holding Company, Oregon Health & Science Univeristy
InventorsRobert DEANS, Richard MAZIARZ, Magdalena KOVACSOVICS, Philip STREETER, Wouter VAN'T HOF
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Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.
-27. (canceled)
A method for ameliorating an immune dysfunction in a subject suffering from an immune dysfunction, said method comprising administering to the subject by an effective route and in a therapeutically effective amount to ameliorate the dysfunction, isolated, expanded human multipotent non-embryonic, non-germ cells that can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal embryonic lineages, are allogeneic or xenogeneic to the subject, wherein the cells have not be genetically engineered to improve their immunological properties.
A method for ameliorating an immune dysfunction in a subject suffering from an immune dysfunction, said method comprising administering to the subject by an effective route and in a therapeutically effective amount to ameliorate the dysfunction, isolated, expanded human multipotent non-embryonic, non-germ cells that express telomerase and are allogeneic or xenogeneic to the subject.
A method for ameliorating an immune dysfunction in a subject suffering from an immune dysfunction, said method comprising administering to the subject by an effective route and in a therapeutically effective amount to ameliorate the dysfunction, isolated, expanded human multipotent non-embryonic, non-germ cells that are positive for oct3/4 and are allogeneic or xenogeneic to the subject;
A method for ameliorating an immune dysfunction in a subject suffering from an immune dysfunction, said method comprising administering to the subject by an effective route and in a therapeutically effective amount to ameliorate the dysfunction, isolated, expanded human multipotent non-embryonic, non-germ cells that have undergone at least 40 cell doublings in culture prior to their use, and are allogeneic or xenogeneic to the subject;
Dependencies are inferred from the claim text.