Long-acting local anesthetic formulation
AssigneeUniversity of Connecticut
InventorsRajesh V. Lalla, Diane J. Burgess, Tingting Li
Life of this patent
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Abstract
Compositions that include a bupivacaine salt are provided. The compositions may include bupivacaine linoleate, bupivacaine linolenate or bupivacaine laurate, at least one thermosensitive polymer, and at least one mucoadhesive or dermoadhesive agent. Also provided are methods for the treatment of an inflammatory or ulcerative condition with the disclosed compositions.
Claims27
A pharmaceutical formulation comprising bupivacaine salt, at least one thermosensitive polymer, and at least one mucoadhesive or dermoadhesive agent.
A spray formulation comprising a bupivacaine salt, at a concentration of about 0.1% weight/volume (w/v) to about 5% w/v of the formulation, at least one thermosensitive polymer at a concentration of about 10% w/v to about 22% w/v of the formulation, and a mucoadhesive or dermoadhesive agent at a concentration of about 0.05% w/v to about 5% w/v of the formulation.
A method for treating a subject having an inflammatory disease or condition, comprising administering to the subject a pharmaceutical formulation comprising a bupivacaine salt, at least one thermosensitive polymer, and at least one mucoadhesive or dermoadhesive agent.
27-50. (canceled)
Dependencies are inferred from the claim text.