Methods of treating conditions related to the s1p1 receptor
AssigneeArena Pharmaceuticals, Inc.
InventorsRonald J. Christopher, Abu J.M. Sadeque
Life of this patent
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Abstract
Provided are methods of treatment of a sphingosine 1-phosphate subtype 1 (S1PI) receptor-associated disorder comprising prescribing and/or administering to an individual in need thereof a standard dose of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indo1-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
Claims81
A method of treating an individual with a sphingosine 1-phosphate subtype 1 (S1P1) receptor-associated disorder comprising:
- administering to the individual in need thereof a pharmaceutical dosage form comprising a therapeutically effective amount of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof,
- wherein the pharmaceutical dosage form has a mean fed/fasted ratio of the area under the plasma concentration versus time curve of from about 0.8 to about 1.25 and a mean fed/fasted ratio of the maximum plasma concentration (Cmax) from about 0.8 to about 1.25.
A method of administering a sphingosine 1-phosphate subtype 1 (S1P1) receptor modulator chosen from (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof, to a patient in need thereof wherein the patient is also being administered a cytochrome P450 (CYP) substrate, organic anion transporter (OAT) substrate, UDP-glucuronosyltransferase (UGT) substrate, cytochrome P450 2C8 (CYP2C8) inhibitor, cytochrome P450 2C9 (CYP2C9) inhibitor, CYP2C8 inducer, CYP2C9 inducer, UDP-glucuronosyltransferase (UGT) enzyme UGT1A1 inhibitor, or UDP-glucuronosyltransferase (UGT) enzyme UGT1A6 inhibitor, comprising:
- administering to the patient a therapeutically effective amount of the S1P1 modulator,
- wherein the therapeutically effective amount of the S1P1 modulator is less than the amount that would be administered to a patient who is not also being administered a CYP substrate, OAT substrate, UGT substrate, CYP2C8 inhibitor, CYP2C9 inhibitor, CYP2C8 inducer, CYP2C9 inducer, UGT1A1 inhibitor, or UGT1A6 inhibitor.
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Dependencies are inferred from the claim text.