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OwnerJuan P. Ianowski, Julian S. Tam +2inventors
InventorsJuan P. Ianowski, Julian S. Tam, Xiaojie Luan, Veronica A. Campanucci
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The present application relates to a method of increasing the volume of an airway surface liquid (ASL) layer and/or increasing mucociliary clearance in a subject. For example, the application relates the use of one or more neuronal agonists such as menthol and/or capsaicin, in combination with hypertonic saline (HTS) or isotonic saline (ITS) for increasing the volume of airway surface liquid (ASL) and/or increasing mucociliary clearance or for treatment of a disease, disorder or condition treatable by increasing the volume of an ASL layer and/or increasing mucociliary clearance. For example, the disease, disorder or condition is cystic fibrosis or a non-cystic fibrosis respiratory disease, disorder or condition such as non-cystic fibrosis bronchiectasis.
A method of increasing the volume of an airway surface liquid (ASL) layer) or treating a disease, disorder or condition that is treatable by increasing the volume of an ASL layer comprising administering an effective amount of one or more neuronal agonists or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in combination with hypertonic saline (HTS) treatment or isotonic saline (ITS) treatment, to a subject in need thereof.
A method of increasing airway clearance or treating a disease, disorder or condition that is treatable by increasing airway clearance comprising administering an effective mount of one or more neuronal agonists, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in combination with hypertonic saline (HTS) treatment or isotonic saline (ITS) treatment, to a subject in need thereof.
A method of increasing mucociliary clearance or treating a disease, disorder or condition that is treatable by increasing mucociliary clearance comprising administering an effective amount of one or more neuronal agonists, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in combination with hypertonic saline (HTS) treatment or isotonic saline (ITS) treatment, to a subject in need thereof.
A method of improving the efficacy of hypertonic saline (HTS) treatment or isotonic saline (ITS) treatment comprising administering an effective amount of one or more neuronal agonists or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, in combination with the HTS treatment, or ITS treatment to a subject in need thereof.
A composition comprising one or more neuronal agonists, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and hypertonic saline (HTS) or isotonic saline (ITS), wherein the one or more neuronal agonists, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and HTS or ITS are present in amounts effective to increase mucociliary clearance or for treating a disease, disorder or condition treatable by increasing mucociliary clearance.
Dependencies are inferred from the claim text.